The substantia nigra of the human brain
Identifieur interne : 002799 ( Main/Corpus ); précédent : 002798; suivant : 002800The substantia nigra of the human brain
Auteurs : P. Damier ; E. C. Hirsch ; Y. Agid ; A. M. GraybielSource :
- Brain [ 0006-8950 ] ; 1999-08.
English descriptors
- KwdEn :
Abstract
To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D28K immunostaining to subdivide the substantia nigra with landmarks independent of the degenerative process. Within the substantia nigra pars compacta, we identified dopamine-containing neurons in the calbindin-rich regions (`matrix') and in five calbindin-poor pockets (`nigrosomes') defined by analysis of the three-dimensional networks formed by the calbindin-poor zones. These zones were recognizable in all of the brains, despite severe loss of dopamine-containing neurons. The degree of loss of dopamine-containing neurons in the substantia nigra pars compacta was related to the duration of the disease, and the cell loss followed a strict order. The degree of neuronal loss was significantly higher in the nigrosomes than in the matrix. Depletion was maximum (98%) in the main pocket (nigrosome 1), located in the caudal and mediolateral part of the substantia nigra pars compacta. Progressively less cell loss was detectable in more medial and more rostral nigrosomes, following the stereotyped order of nigrosome 1 > nigrosome 2 > nigrosome 4 > nigrosome 3 > nigrosome 5. A parallel, but lesser, caudorostral gradient of cell loss was observed for dopamine-containing neurons included in the matrix. This pattern of neuronal loss was consistent from one parkinsonian substantia nigra pars compacta to another. The spatiotemporal progression of neuronal loss related to disease duration can thus be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression.
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DOI: 10.1093/brain/122.8.1437
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ISTEX:64163AC66DA877833F215B2F848C1C1C4140E121Le document en format XML
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A parallel, but lesser, caudorostral gradient of cell loss was observed for dopamine-containing neurons included in the matrix. This pattern of neuronal loss was consistent from one parkinsonian substantia nigra pars compacta to another. The spatiotemporal progression of neuronal loss related to disease duration can thus be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>P. Damier</name><affiliations><json:string>INSERM U289, Hôpital de la Salpêtrière, Paris, France and</json:string><json:string>Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>E. C. 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Patterns of loss of dopamine-containing neurons in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>OUP</p></availability><date>1999</date></publicationStmt><notesStmt><note>Dr P. Damier, INSERM U289, Hôpital de la Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France E-mail: cic.salpetriere@psl.ap-hop-paris.fr</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The substantia nigra of the human brain</title><title level="a" type="sub" xml:lang="en">II. Patterns of loss of dopamine-containing neurons in Parkinson's disease</title><author><persName><forename type="first">P.</forename><surname>Damier</surname></persName><affiliation></affiliation><affiliation></affiliation></author><author><persName><forename type="first">E. 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A parallel, but lesser, caudorostral gradient of cell loss was observed for dopamine-containing neurons included in the matrix. This pattern of neuronal loss was consistent from one parkinsonian substantia nigra pars compacta to another. The spatiotemporal progression of neuronal loss related to disease duration can thus be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>KWD</head><item><term>Parkinson's disease</term></item><item><term>dopamine</term></item><item><term>calbindin</term></item><item><term>substantia nigra</term></item><item><term>basal ganglia</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>ABR</head><item><term>TH = tyrosine hydroxylase</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/64163AC66DA877833F215B2F848C1C1C4140E121/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">brain</journal-id><journal-id journal-id-type="nlm-ta">Brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-title>Brain</journal-title><abbrev-journal-title abbrev-type="publisher">Brain</abbrev-journal-title><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">1221437</article-id><article-id pub-id-type="doi">10.1093/brain/122.8.1437</article-id><title-group><article-title>The substantia nigra of the human brain</article-title><subtitle>II. Patterns of loss of dopamine-containing neurons in Parkinson's disease</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Damier</surname><given-names>P.</given-names></name><xref rid="AFF1">1</xref><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hirsch</surname><given-names>E. C.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Agid</surname><given-names>Y.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Graybiel</surname><given-names>A. M.</given-names></name><xref rid="AFF2">2</xref></contrib><aff id="AFF1"><label>1</label>INSERM U289, Hôpital de la Salpêtrière, Paris, France and </aff><aff id="AFF2"><label>2</label>Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA</aff></contrib-group><author-notes><corresp>Dr P. Damier, INSERM U289, Hôpital de la Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France E-mail: <ext-link xlink:href="cic.salpetriere@psl.ap-hop-paris.fr" ext-link-type="email">cic.salpetriere@psl.ap-hop-paris.fr</ext-link></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>1999</year></pub-date><volume>122</volume><issue>8</issue><fpage>1437</fpage><lpage>1448</lpage><history><date date-type="accepted"><day>15</day><month>03</month><year>1999</year></date><date date-type="received"><day>10</day><month>12</month><year>1998</year></date><date date-type="rev-recd"><day>11</day><month>03</month><year>1999</year></date></history><copyright-statement>© Oxford University Press 1999</copyright-statement><copyright-year>1999</copyright-year><abstract xml:lang="en"><p>To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D<sub>28K</sub> immunostaining to subdivide the substantia nigra with landmarks independent of the degenerative process. Within the substantia nigra pars compacta, we identified dopamine-containing neurons in the calbindin-rich regions (`matrix') and in five calbindin-poor pockets (`nigrosomes') defined by analysis of the three-dimensional networks formed by the calbindin-poor zones. These zones were recognizable in all of the brains, despite severe loss of dopamine-containing neurons. The degree of loss of dopamine-containing neurons in the substantia nigra pars compacta was related to the duration of the disease, and the cell loss followed a strict order. The degree of neuronal loss was significantly higher in the nigrosomes than in the matrix. Depletion was maximum (98%) in the main pocket (nigrosome 1), located in the caudal and mediolateral part of the substantia nigra pars compacta. Progressively less cell loss was detectable in more medial and more rostral nigrosomes, following the stereotyped order of nigrosome 1 > nigrosome 2 > nigrosome 4 > nigrosome 3 > nigrosome 5. A parallel, but lesser, caudorostral gradient of cell loss was observed for dopamine-containing neurons included in the matrix. This pattern of neuronal loss was consistent from one parkinsonian substantia nigra pars compacta to another. The spatiotemporal progression of neuronal loss related to disease duration can thus be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression.</p></abstract><kwd-group kwd-group-type="KWD" xml:lang="en"><kwd>Parkinson's disease</kwd><kwd>dopamine</kwd><kwd>calbindin</kwd><kwd>substantia nigra</kwd><kwd>basal ganglia</kwd></kwd-group><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>TH = tyrosine hydroxylase</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>1437</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Article</meta-value></custom-meta></custom-meta-wrap></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The substantia nigra of the human brain</title><subTitle>II. Patterns of loss of dopamine-containing neurons in Parkinson's disease</subTitle></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>The substantia nigra of the human brain</title><subTitle>II. Patterns of loss of dopamine-containing neurons in Parkinson's disease</subTitle></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Damier</namePart><affiliation></affiliation><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. C.</namePart><namePart type="family">Hirsch</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Agid</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. M.</namePart><namePart type="family">Graybiel</namePart><affiliation></affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1999-08</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D28K immunostaining to subdivide the substantia nigra with landmarks independent of the degenerative process. Within the substantia nigra pars compacta, we identified dopamine-containing neurons in the calbindin-rich regions (`matrix') and in five calbindin-poor pockets (`nigrosomes') defined by analysis of the three-dimensional networks formed by the calbindin-poor zones. These zones were recognizable in all of the brains, despite severe loss of dopamine-containing neurons. The degree of loss of dopamine-containing neurons in the substantia nigra pars compacta was related to the duration of the disease, and the cell loss followed a strict order. The degree of neuronal loss was significantly higher in the nigrosomes than in the matrix. Depletion was maximum (98%) in the main pocket (nigrosome 1), located in the caudal and mediolateral part of the substantia nigra pars compacta. Progressively less cell loss was detectable in more medial and more rostral nigrosomes, following the stereotyped order of nigrosome 1 > nigrosome 2 > nigrosome 4 > nigrosome 3 > nigrosome 5. A parallel, but lesser, caudorostral gradient of cell loss was observed for dopamine-containing neurons included in the matrix. This pattern of neuronal loss was consistent from one parkinsonian substantia nigra pars compacta to another. The spatiotemporal progression of neuronal loss related to disease duration can thus be drawn in the substantia nigra pars compacta for each Parkinson's disease patient: depletion begins in the main pocket (nigrosome 1) and then spreads to other nigrosomes and the matrix along rostral, medial and dorsal axes of progression.</abstract><note type="author-notes">Dr P. Damier, INSERM U289, Hôpital de la Salpêtrière, 47, boulevard de l'hôpital, 75013 Paris, France E-mail: cic.salpetriere@psl.ap-hop-paris.fr</note><subject lang="en"><genre>KWD</genre><topic>Parkinson's disease</topic><topic>dopamine</topic><topic>calbindin</topic><topic>substantia nigra</topic><topic>basal ganglia</topic></subject><subject lang="en"><genre>ABR</genre><topic>TH = tyrosine hydroxylase</topic></subject><relatedItem type="host"><titleInfo><title>Brain</title></titleInfo><titleInfo type="abbreviated"><title>Brain</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0006-8950</identifier><identifier type="eISSN">1460-2156</identifier><identifier type="PublisherID">brainj</identifier><identifier type="PublisherID-hwp">brain</identifier><identifier type="PublisherID-nlm-ta">Brain</identifier><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1437</start><end>1448</end></extent></part></relatedItem><identifier type="istex">64163AC66DA877833F215B2F848C1C1C4140E121</identifier><identifier type="DOI">10.1093/brain/122.8.1437</identifier><identifier type="local">1221437</identifier><accessCondition type="use and reproduction" contentType="copyright">© Oxford University Press 1999</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/64163AC66DA877833F215B2F848C1C1C4140E121/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= The substantia nigra of the human brain
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